Denigma: Factor

MLH1

Symbol: MLH1
Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Entrez gene ID: 4292
Ensembl gene ID: ENSG00000076242
Species: Human (Taxid: 9606)

Observation:

3 SNPs in the coding region of MLH1 were analyzed in 85 Korean centenarians and in 106 Korean controls. The CAT haplotype (C670, A676 and T1172) frequency was significantly higher in the centenarians than in the controls [16474933]. MLH1 was found to be associated with longevity [22406557].

Assays: Organismal Lifespan

Longevity Associated Variants:

rs13320360 0.0036 [22406557]

Classification:

Longevity-Associated

Type:

Gene

Protein coding

References:

16474933: Association between the MLH1 gene and longevity.

22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Aging Relevance Analysis/Source:

GenAge