INSR

Symbol: INSR
Name: insulin receptor
Entrez gene ID: 3643
Ensembl gene ID: ENSG00000171105
Species: Human

Observation:

5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • 32 SNPs, not specified None [19489743]
  • rs3745548 0.057 [15582274]
  • rs2252673 0.083 [15582274]
  • rs3745546 0.168 [15582274]
  • rs1799817 0.205 [15582274]
  • rs2288404 0.277 [15582274]
  • rs3745544 0.441 [15582274]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 15582274: Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • INSR (9606)
  • INSR (9615)
  • INSR (9913)
  • Insr (10090)
  • Insr (10116)
  • INSR (9031)
  • insrb (7955)
  • insra (7955)

  • Orthologs
  • daf-2 (6239)
  • daf-2 (6239)

  • Inparanoids
  • ENSMUSP00000088837 (10090)
  • ENSRNOP00000046668 (10116)
  • ENSMMUP00000004959 (9544)



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