IL10

Symbol: IL10
Name: interleukin 10
Entrez gene ID: 3586
Ensembl gene ID: ENSG00000136634
Species: Human (Taxid: 9606)


Observation:

The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs1800896 0.031 [20518833]
  • IL10 haplotypes 0.05 [21299522]
  • IL10 haplotypes 0.05 [21299522]
  • −1082 G/A 0.025 [11857058]
  • --1082G-->A 0.0001 [15466015]
  • rs1800896 0.019 [12676903]
  • rs1800896 - rs1800629 0.038 [12676903]
  • rs1800896 0.64 [11640949]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 11857058: Gender-specific association between -1082 IL-10 promoter polymorphism and longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IL10 (9606)
  • IL10 (9598)
  • IL10 (9615)
  • IL10 (9913)
  • Il10 (10090)
  • Il10 (10116)
  • IL10 (9031)
  • il10 (7955)
  • LOC100331157 (7955)



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