Denigma

HSPA1A

Symbol: HSPA1A
Name: heat shock 70kDa protein 1A
Entrez gene ID: 3303
Ensembl gene ID: ENSG00000204389
Species: Human (Taxid: 9606)


Observation:

(A/C)-110 polymorphism in the HSPA1A gene was examined in 591 subjects (263 males and 328 females; age range 18-109 years; 36 male and 84 female centenarians). A significant age-related decrease of the frequency of allele (A)-110 was observed in females, while no difference was observed in the males [14501185].HSPA1A was found to be associated with longevity [16804002]. HSPA1A was found to be associated with longevity [14501185]. HSPA1A was found to be associated with longevity [16804002]. HSPA1A was found to be associated with longevity [20388090]. HSPA1A was found to be associated with longevity [20388090].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs1008438 0.016 [20388090]
  • rs1061581 0.039 [20388090]
  • rs1061581-rs1043618-rs2227956 0.016 [19840767]
  • rs1061581-rs1043618-rs2227956 0.025 [19840767]
  • rs1008438 0.009 [16896546]
  • rs1008438 0.005 [16804002]
  • rs1008438 0.005 [16804002]

    • Classification:
  • Longevity-Associated


    • Type:
  • Gene
  • Protein coding

    References:
  • 14501185: The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HSPA1A (9606)
  • HSPA1B (9606)
  • HSP70 (9615)
  • HSPA1A (9913)
  • Hspa1b (10090)
  • Hspa1a (10090)
  • Hspa1b (10116)
  • LOC100333726 (7955)
  • Hsp70Ab (7227)
  • Hsp68 (7227)
  • Hsp70Aa (7227)
  • Hsp70Bc (7227)
  • Hsp70Ba (7227)
  • Hsp70Bb (7227)
  • Hsp70Bbb (7227)
  • SSA3 (4932)
  • KLLA0E20527g (28985)
  • AGOS_AER187W (33169)
  • AT3G09440 (3702)



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