Denigma

HLA-DRB1

Symbol: HLA-DRB1
Name: major histocompatibility complex, class II, DR beta 1
Entrez gene ID: 3123
Ensembl gene ID: ENSG00000196126
Species: Human (Taxid: 9606)


Observation:

Polymorphisms in the HLA-DRB1 gene in Okinawan centenarians were analyzed. DRB11401 allele was significantly increased in the centenarians while DRB10101 and DRB1*1201 alleles were slightly decreased [9389323].HLA-DRB1 was found to be associated with longevity [9425225].HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9389323]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [20426625]. HLA-DRB1 was not found to be associated with longevity [16269080].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • HLA-DRB1 13 generic DRB1 alleles 0.01 [9425225]
  • HLA-DRB1 13 generic DRB1 alleles 0.001 [9425225]
  • HLA-DRB1 13 generic DRB1 alleles 0.01 [9425225]
  • DR7 0.01 [9425225]
  • DR11 0.01 [9425225]
  • DR13 0.01 [9425225]
  • HLA-DRB1*15 None [12581796]
  • HLA-B8,DR3 None [12581796]
  • HLA-DRB1*1101 None [16269080]
  • HLA DRB1*18 0.0266 [20426625]
  • HLA-DRB1 haplotypes 0.004 [9389323]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • HLA-DRB1 (9606)
  • PATR-DQB1 (9598)
  • H2-Eb1 (10090)
  • RT1-Db1 (10116)
  • si:busm1-228j01.6 (7955)
  • zgc:123114 (7955)
  • si:busm1-228j01.4 (7955)
  • si:busm1-37i06.4 (7955)
  • zgc:153067 (7955)
  • mhc2dcb (7955)
  • si:busm1-194e12.12 (7955)
  • LOC100332621 (7955)
  • mhc2dab (7955)
  • zgc:152682 (7955)
  • si:busm1-160c18.3 (7955)
  • LOC100332219 (7955)
  • zgc:103700 (7955)
  • wu:fd58b11 (7955)
  • LOC100332155 (7955)

    • Inparanoids
  • ENSRNOP00000000522 (10116)
  • ENSMMUP00000002057 (9544)



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