HFE

Symbol: HFE
Name: hemochromatosis
Entrez gene ID: 3077
Ensembl gene ID: ENSG00000010704
Species: Human (Taxid: 9606)


Observation:

C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • H63D 1.0 [11857056]
  • S65C 1.0 [11857056]
  • HFE C282Y 7.2e-07 [11857056]
  • rs1800730 None [12714263]
  • rs1799945 0.008 [12714263]
  • rs1800562 None [12714263]
  • rs1799945 None [12714263]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 11857056: Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HFE (9606)
  • HFE (9598)
  • HFE (9913)
  • Hfe (10090)



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