AKAP10

Symbol: AKAP10
Name: A kinase (PRKA) anchor protein 10
Entrez gene ID: 11216
Ensembl gene ID: ENSG00000108599
Species: Human

Observation:

Male (n= 4766) and female (n = 6202) divided into young (183-9 years) and old (60 years) groups were examined for polymorphisms. A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females [12646697].



Assays: Organismal Lifespan

Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 12646697: Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AKAP10 (9606)
  • AKAP10 (9615)
  • AKAP10 (9913)
  • Akap10 (10090)
  • Akap10 (10116)
  • AKAP10 (9031)
  • akap10 (7955)
  • pkaap (7227)
  • AgaP_AGAP007895 (7165)
  • rgs-5 (6239)

  • Inparanoids
  • ENSP00000225737 (9606)
  • ENSMUSP00000099710 (10090)
  • ENSRNOP00000003871 (10116)
  • ENSMMUP00000035109 (9544)
  • ENSP00000225737 (9606)



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