APOA1

Symbol: APOA1
Name: apolipoprotein A-I
Entrez gene ID: 335
Ensembl gene ID: ENSG00000118137
Species: Human (Taxid: 9606)


Observation:

APOA1-MspI-RFLP (-75 nt from the transcription starting site) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years). The APOA1 allele P, which increases serum LDL-C at middle-age and is over-represented in cardiovascular diseases, tends to increase its frequency in the centenarians males [12556235].APOA1 was found to be associated with longevity [12556235].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • APOA1-MspI-RFLP A/P alleles 0.045 [12556235]
  • APOA1-MspI-RFLP (−75) 0.016 [12556235]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 12556235: The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • APOA1 (9606)
  • APOA1 (9598)
  • APOA1 (9615)
  • APOA1 (9913)
  • Apoa1 (10090)
  • APOA1 (9031)
  • APOA1 (9031)
  • apoa1 (7955)



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