Denigma

AGT

Symbol: AGT
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Entrez gene ID: 183
Ensembl gene ID: ENSG00000135744
Species: Human (Taxid: 9606)


Observation:

M/T235 SNP in the AGT gene was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) and a significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele [11602206].AGT was found to be associated with longevity [15621215]. AGT was found to be associated with longevity [11602206]. AGT was not found to be associated with longevity [15621215].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • - None [15621215]
  • AGT 1.0 [15621215]
  • M/T235 0.53 [11602206]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 11602206: Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • AGT (9606)
  • AGT (9598)
  • AGT (9615)
  • AGT (9913)
  • Agt (10090)
  • Agt (10116)
  • AGT (9031)
  • agt (7955)

    • Inparanoids
  • ENSMUSP00000066488 (10090)
  • ENSRNOP00000024917 (10116)
  • ENSMMUP00000007736 (9544)



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