Denigma: Factor

PCMT1

Symbol: PCMT1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase
Entrez gene ID: 5110
Ensembl gene ID: ENSG00000120265
Species: Human (Taxid: 9606)

Observation:

The distribution of genotypes in a healthy older population of Ashenazi Jewish individuals with that in a younger ethnically matched control group were compared. 65% of the healthy older population had the heterozygous genotype, greater than the 50% expected by Hardy-Weinberg equilibrium, suggesting a possible selection for having both alleles of the repair methyltransferase in successful aging [10496068].PCMT1 was found to be associated with longevity [10496068].

Assays: Organismal Lifespan

Longevity Associated Variants:

Ile119Val 0.049 [10496068]

Classification:

Longevity-Associated

Type:

Gene

Protein coding

References:

10496068: Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins.

Aging Relevance Analysis/Source:

GenAge