Symbol: APOC3
Name: apolipoprotein C-III
Entrez gene ID: 345
Ensembl gene ID: ENSG00000110245
Species: Human
(Taxid: 9606)
Observation:
Several small nucleotide polymorphisms in the APOC3 gene were associated with longevity [8018664; 11193221; 16602826].
The Sst I polymorphism was examined in 179 Finnish centenarians. The S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%) [8018664].
Assays:
Organismal Lifespan
Longevity Associated Variants:
rs2542052 0.0001 [16602826]
APOC3-SstI-RFLP (3'UTR, 3238 nt) 0.05 [12556235]
APOC3 T455C 0.05 [11193221]
T-455C 0.005 [11193221]
rs2542052 0.001 [16602826]
rs2542052 0.0001 [16602826]
rs2542052 0.0001 [16602826]
rs2542052 None [18034366]
Classification:
Longevity-Associated
Type:
Gene
Protein coding
References:
8018664: Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.
11193221: Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population.
16602826: Lipoprotein genotype and conserved pathway for exceptional longevity in humans.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
APOC3
(9606)
APOC3
(9598)
APOC3
(9615)
APOC3
(9913)
Apoc3
(10090)
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