APOC3

Symbol: APOC3
Name: apolipoprotein C-III
Entrez gene ID: 345
Ensembl gene ID: ENSG00000110245
Species: Human (Taxid: 9606)


Observation:

Several small nucleotide polymorphisms in the APOC3 gene were associated with longevity [8018664; 11193221; 16602826].

The Sst I polymorphism was examined in 179 Finnish centenarians. The S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%) [8018664].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2542052 0.0001 [16602826]
  • APOC3-SstI-RFLP (3'UTR, 3238 nt) 0.05 [12556235]
  • APOC3 T455C 0.05 [11193221]
  • T-455C 0.005 [11193221]
  • rs2542052 0.001 [16602826]
  • rs2542052 0.0001 [16602826]
  • rs2542052 0.0001 [16602826]
  • rs2542052 None [18034366]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 8018664: Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.
  • 11193221: Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population.
  • 16602826: Lipoprotein genotype and conserved pathway for exceptional longevity in humans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • APOC3 (9606)
  • APOC3 (9598)
  • APOC3 (9615)
  • APOC3 (9913)
  • Apoc3 (10090)



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