YTHDF2

Symbol: YTHDF2
Name: YTH domain family, member 2
Entrez gene ID: 51441
Ensembl gene ID: ENSG00000198492
Species: Human (Taxid: 9606)


Observation:

A locus associated with human longevity corresponds to (TG)n microsatellite is located in the YTHDF2 gene. 412 participants of different ages, including 137 centenarians, were genotyped. The increased homozygosity in centenarians at this locus was confirmed, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. The same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. [16799135].YTHDF2 was found to be associated with longevity [16799135].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs28969505 0.023 [16799135]
  • rs28969505 0.047 [16799135]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 16799135: A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • YTHDF2 (9606)
  • YTHDF2 (9598)
  • YTHDF2 (9615)
  • YTHDF2 (9913)
  • Ythdf2 (10090)
  • Ythdf2 (10116)
  • yth2 (7955)

  • Inparanoids
  • ENSMUSP00000099630 (10090)
  • ENSRNOP00000053055 (10116)
  • ENSMMUP00000014948 (9544)
  • ENSP00000362918 (9606)



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