Denigma: Factor

pex16

Symbol: pex16
Name: peroxin 16
Entrez gene ID: 40293
Ensembl gene ID: FBgn0037019
Species: Fly (Taxid: 7227)

Observation:

pex16 mutation lead to a reduced mean lifespan of one-third in females and on-fourth in males. The short lifespan can be rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons [21826223].

Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects in the development of the nervous system [21826223].

Interventions:

pex16 mutation -33 to -75%

Assays: Organismal Lifespan
Mean: -33 to --75

Classification:

Aging-Suppressor

Negative Aging-Suppressor

Type:

Gene

Protein coding

References:

21826223: Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.

Aging Relevance Analysis/Source:

GenAge