Denigma

Ercc4

Symbol: Ercc4
Name: Excision repair cross-complementing rodent repair deficiency, complementation group 4
Entrez gene ID: 50505
Ensembl gene ID: ENSMUSG00000022545
Species: Mouse (Taxid: 10090)

Functional description:
Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity). [UniProt]

Observation:

ERCC4-ERCC1-deficient mice exhibit signs of premature aging [17183314].



Interventions:
  • ERCC1 and ERCC4 deficieny

    • Assays: Organismal Lifespan

    Classification:
  • Aging Associated


    • References:
  • 17183314: A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ERCC4 (9606)
  • ERCC4 (9598)
  • ERCC4 (9615)
  • Ercc4 (10090)
  • Ercc4 (10116)
  • ERCC4 (9031)
  • ercc4 (7955)
  • mei-9 (7227)
  • AgaP_AGAP002805 (7165)
  • rad16 (4896)
  • RAD1 (4932)
  • KLLA0D12210g (28985)
  • AGOS_AFR456C (33169)
  • GeneID:2682357 (148305)
  • NCU07440 (5141)
  • UVH1 (3702)
  • Os03g0100400 (4530)

    • Inparanoids
  • ENSMUSP00000023206 (10090)
  • ENSRNOP00000004563 (10116)
  • YPL022W (4932)
  • SPCC970.01 (4896)
  • ENSMUSP00000023206 (10090)
  • ENSMUSP00000023206 (10090)
  • ENSMUSP00000023206 (10090)



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