Lnk

Symbol: Lnk
Entrez gene ID: 43130
Ensembl gene ID: FBgn0028717
Species: Fly (Taxid: 7227)


Observation:

Loss of Lnk function results in increased median (14% in females and 17.5 in males) and maximum lifespan, reduced female fecundity and improves survival under conditions of oxidative stress and starvation. Heterozygousity does not result in any significant differences in lifespan in either males or females. Moreover, lifespan extension in one of the female homozygous mutant is fully rescued by the introduction of a Lnk genomic rescue construct [20333234].



Interventions:
  • Lnk mutation -14 to -17.5%

  • Assays: Organismal Lifespan
    Median: -14 to -17.5

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Type:
  • Gene
  • Protein coding

    References:
  • 20333234: Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Lnk (7227)
  • AgaP_AGAP003863 (7165)

  • Inparanoids
  • ENSMUSP00000095657 (10090)
  • ENSRNOP00000001935 (10116)
  • ENSMMUP00000030963 (9544)
  • ENSP00000352232 (9606)



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