TSA

Symbol: TSA
Name: Trichostatin A
Entrez gene ID: 7001
Ensembl gene ID: ENSG00000167815
Species: Human
Function:
Histone deacetylase inhibitor

Observation:

Histone deacetylase inhibitor Trichostatin A (TSA) extends the lifespan of Drosophila melanogaster by promoting the hsp22 gene transcription, and affecting the chromatin morphology at the locus of hsp22 gene along the polytene chromosome [15346199].

hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762].



Interventions:
  • Trichostatin A supplementation +25%

  • Assays: Organismal Lifespan
    Mean: +25

    Classification:
  • Gero-Suppressant


  • Type:
  • Drug

    References:
  • 15346199: Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression.
  • 15695762: Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRDX2 (9606)
  • PRDX2 (9598)
  • PRDX2 (9615)
  • PRDX2 (9913)
  • Prdx2 (10090)
  • Prdx2 (10116)
  • prdx2 (7955)
  • Jafrac1 (7227)
  • TPX2 (7165)
  • prdx-2 (6239)
  • tpx1 (4896)
  • TSA1 (4932)
  • 2-Cys_Prx_B (3702)
  • AT3G11630 (3702)
  • Os02g0537700 (4530)
  • TPx1 (5833)
  • TPx2 (5833)

  • Inparanoids
  • ENSP00000301522 (9606)
  • ENSMUSP00000105356 (10090)
  • ENSRNOP00000004799 (10116)
  • ENSMMUP00000007512 (9544)
  • YML028W (4932)
  • SPCC576.03c (4896)
  • ENSP00000301522 (9606)



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