Gr63a

Symbol: Gr63a
Name: Gustatory receptor 63a
Entrez gene ID: 38453
Ensembl gene ID: FBgn0035468
Species: Fly (Taxid: 7227)


Observation:

Gr63a loss-of-function in female flies leads to 30% extended mean lifespan, increased fat deposition, and enhanced resistance to some (but not all) environmental stresses. Lifespan of males is not extended [20422037].

Overexpression of Gr63a has modest negative effect on lifespan [20422037].



Interventions:
  • Gr63a mutation +30%
  • Gr63a overexpression

  • Assays: Organismal Lifespan
    Mean: +30

    Classification:
  • Gerontogene
  • Negative Gerontogene
  • Positive Gerontogene


  • Type:
  • Gene
  • Protein coding

    References:
  • 20422037: Carbon dioxide sensing modulates lifespan and physiology in Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Gr63a (7227)
  • GPRGR24 (7165)



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