Dys

Symbol: Dys
Name: Dystroglycan
Entrez gene ID: 36773
Ensembl gene ID: FBgn0034072
Species: Fly (Taxid: 7227)


Observation:

Loss of dys function in the heart leads to an age-dependent disruption of the myofibrillar organization within the myocardium as well as to alterations in cardiac performance. dys RNAi-mediated knockdown in the mesoderm also shortens lifespan. Mesodermal dys knockout results in a morderate maximum lifespan reduction (13%), but not when exclusively targeted to the heart. In contrast, half of the transheteozygous DysExel618/Dyskx43 deficiency flies die at 29 days compared to 63 days in controls. This indicates that a moderate dye loss-of-function in all muscles, but not in just the heart, reduces the normal lifespan [18221418].



Interventions:
  • dys knockout -13%
  • dys RNAi

  • Assays: Organismal Lifespan
    Maximum: -13

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 18221418: Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • Dg (7227)
  • AgaP_AGAP005162 (7165)

  • Inparanoids
  • ENSMUSP00000079294 (10090)
  • ENSRNOP00000026327 (10116)



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