Denigma

DNApol-gamma35

Symbol: DNApol-gamma35
Name: DNA polymerase gamma 35kD
Entrez gene ID: 3772064
Ensembl gene ID: FBgn0004407
Species: Fly (Taxid: 7227)


Observation:

Overexpression of DNApol-gamma35 (DNA polymerase gamma) in the nervous system results in a decrease in the median lifespan ranging from 39% to 52% [17999718].



Interventions:
  • DNApol-gamma35 overexpression -39 to -52%

    • Assays: Organismal Lifespan
    Mean: -39 to -52

    Classification:
  • Gerontogene
  • Negative Gerontogene


    • Type:
  • Gene
  • Protein coding

    References:
  • 17999718: Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • DNApol-gamma35 (7227)
  • AgaP_AGAP000979 (7165)



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