Symbol: Nudt1 Name: nudix (nucleoside diphosphate linked moiety X)-type motif 1 Alias: Mth1 Entrez gene ID: 17766 Ensembl gene ID: ENSMUSG00000036639 Species: Mouse (Taxid: 10090) Observation: hMTH1-Tg mice express high levels of the hMTH1 hydrolase that degrades 8-oxoGTP and 8-oxoGTP and excludess 8-oxoguanine from both DNA and RNA. hMTH1-overexpresing mice have significantly lower steady-state levels of 8-oxoguanine in both nuclear and mitochondrial DNA of several organs, including the brain. hMTH1 overexpression prevents the age-dependent accumulation of DNA 8-oxoguanine that occurs in the wild-type mice. These lower levels of oxidized guanines are associated with increased longevity and hMTH1-Tg animals live significantly longer than their wild-type littermates [23648059]. Interventions: Assays: Organismal Lifespan Classification: Type: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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