Denigma: Factor

DATS

Symbol: DATS
Name: Diallyl Trisulfide

Function:
Garlic constituent

Observation:

DATS increases longevity apparently by enhancing skn-1.

Treatment with 5-10 μM DATS increases lifespan even when treatment is started during young adulthood. DATS increases the lifespan of daf-2 and daf-16 mutants, but not that of eat-2 mutants.

DATS treatment leads to the induction of the skn-1 target gene gst-4 and this induction is dependent on skn-1. DATS effect on lifespan is dependent on skn-1 activity in both intestine and ASI neurons [21296648].

Interventions:

DATS treatment

Assays: Organismal Lifespan

Classification:

Gero-Suppressant

DR-Mimetic

Type:

Drug

References:

21296648: The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.

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