Drd4

Symbol: Drd4
Name: Dopamine D4 Receptor
Entrez gene ID: 13491
Ensembl gene ID: ENSMUSG00000025496
Species: Mouse (Taxid: 10090)


Observation:

Drd4 knockout mice, when compared with wild-type and heterozygous mice, display a 7 - 9.7% decrease in lifespan, reduced spontaneous locomotor activity, and no lifespan increase when reared in an enriched environment [23283341].



Interventions:
  • Drd4 knockout -7 to -9.7%

  • Assays: Organismal Lifespan
    Mean: -7 to -9.7

    Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 23283341: DRD4 Genotype Predicts Longevity in Mouse and Human.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • DRD4 (9606)
  • DRD4 (9598)
  • Drd4 (10090)
  • Drd4 (10116)
  • DRD4 (9031)
  • drd4a (7955)
  • drd4b (7955)

  • Inparanoids
  • ENSRNOP00000024137 (10116)
  • ENSMUSP00000026569 (10090)
  • ENSMUSP00000026569 (10090)



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