Denigma

DRD4

Symbol: DRD4
Name: Dopamine D4 Receptor
Entrez gene ID: 1815
Ensembl gene ID: ENSG00000069696
Species: Human (Taxid: 9606)


Observation:

DRD4 7R allele frequency is correlated with longevity. DRD4 moderates the impact of environments on behaviour and health. The oldest population have a 66% increase in individuals carrying the DRD4 7R allele relative to the younger ones and this genotype is strongly correlated with increased levels of physical activity [23283341].DRD4 was found to be associated with longevity [23283341]. DRD4 was found to be associated with longevity [15621215]. DRD4 was not found to be associated with longevity [15621215].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • DRD4 haplotypes None [23283341]
  • DRD4 7R allele 3.5e-08 [23283341]
  • - None [15621215]
  • DRD4 1.0 [15621215]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • References:
  • 23283341: DRD4 Genotype Predicts Longevity in Mouse and Human.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • DRD4 (9606)
  • DRD4 (9598)
  • Drd4 (10090)
  • Drd4 (10116)
  • DRD4 (9031)
  • drd4a (7955)
  • drd4b (7955)

    • Inparanoids
  • ENSMUSP00000026569 (10090)
  • ENSRNOP00000024137 (10116)
  • ENSMMUP00000037850 (9544)



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