2-MEA

Symbol: 2-MEA
Name: 2-Mercaptoethylanime hydrochloride
Species: Mouse (Taxid: 10090)

Function:
Antioxidant

Observation:

Addition of 1% by weight 2-MEA to the diet of male LAF mice, started shortly after weaning, increases average lifespan by approximately 30%, but does not extend maximum lifespan [5723482; 11795501].

Addition of 2-MEA to the maternal diet of female mice increases the lifespan of male and female offspring by 15 and 8%, respectively [Harman & Eddy, 1979; 11795501].

Addition of 2-MEA of an antioxidant mixture containing ethoxyquin and 2-MEA to the diet of dietary restricted mice shortens lifespan approximately 20% [2394907].

References

Harman, D., and Eddy, D. E. (1979). Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: possible explanation of the sex difference in longevity. Age 2, 109-22.



Assays: Organismal Lifespan
Mean: +30

Classification:
  • Gero-Suppressant


  • References:
  • 11795501: Aging: overview.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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