eft-2

Symbol: eft-2
Name: Elongation FacTor
Entrez gene ID: 172743
Ensembl gene ID: F25H5.4
Species: Worm (Taxid: 6239)

Functional description:
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues. [UniProt]

Observation:

Post-developmental RNA interference reduces mean lifespan by 15% [17673661]. Knockdown of eft-2 started after the animal reached the late L4 stage increases mean lifespan by 6-27% and 8%, respectively [22103665].



Interventions:
  • eft-2 RNAi -15 to +27% +8%

  • Assays: Organismal Lifespan
    Mean: -15 to +27
    Maximum: +8

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • eef2b (7955)
  • Ef2b (7227)
  • AgaP_AGAP009441 (7165)
  • eft-2 (6239)
  • AT3G12915 (3702)
  • Os02g0519900 (4530)
  • Os04g0118400 (4530)
  • PF14_0486 (5833)

  • Note: Discrepance!

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