Atg7

Symbol: Atg7
Name: Autophagy-specific gene 7
Entrez gene ID: 37141
Ensembl gene ID: FBgn0034366
Species: Fly (Taxid: 7227)

Functional description:
Involved in autophagy; Autophagy-specific gene 7; Autophagy-specific gene 7 [Source:FlyBase gene name;Acc:FBgn0034366] [Ensembl]; The gene Autophagy-specific gene 7 is referred to in FlyBase by the symbol Dmel\Atg7 (CG5489, FBgn0034366). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity; nucleotide binding. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; macroautophagy; regulation of defense response to virus; regulation of autophagy; larval midgut cell programmed cell death. 11 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; egg; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: E1-like protein-activating enzyme Gsa7p/Apg7p; Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late larval stages, during early pupal stages. [FlyBase]

Observation:

Knockouts of Atg7 are short-lived with a 30% reduction in maximum lifespan and are hypersensitive to nutrient and oxidative stress [18056421; 19550147].



Interventions:
  • Atg7 knockout -30%

  • Assays: Organismal Lifespan
    Maximum: -30

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ATG7 (9606)
  • ATG7 (9615)
  • ATG7 (9913)
  • Atg7 (10090)
  • Atg7 (10116)
  • ATG7 (9031)
  • atg7 (7955)
  • Atg7 (7227)
  • AgaP_AGAP010303 (7165)
  • atg-7 (6239)
  • SPBC6B1.05c (4896)
  • ATG7 (4932)
  • KLLA0A05137g (28985)
  • AGOS_AER298C (33169)
  • GeneID:2683193 (148305)
  • NCU06672 (5141)
  • APG7 (3702)
  • Os01g0614900 (4530)

  • Orthologs
  • atg-7 (6239)
  • atg-7 (6239)

  • Inparanoids
  • FBpp0085891 (7227)
  • ENSMUSP00000032457 (10090)
  • ENSRNOP00000010265 (10116)
  • ENSMMUP00000028718 (9544)
  • ENSP00000346437 (9606)
  • YHR171W (4932)
  • SPBC6B1.05c (4896)

  • Note: GenAge reports a wrong study on mammalian which does not provide any data on Atg7 in fruit flies, right?

    Edit \ Update (Admin) | Delete

    Comment on This Data Unit