MDB4

Symbol: MDB4
Name: methyl-CpG binding domain protein 4
Entrez gene ID: 8930
Ensembl gene ID: ENSG00000129071
Species: Human (Taxid: 9606)

Function:
MDB4 can bind to methylated DNA, is linked to DNA repair and mutations and knockdowns of MBD4 leads to increased genomic instability [10097147; 19854937].

Observation:

Methylation marker cg27193080 is significantly associated with age and its methylation fraction is influenced by the SNP variantrs140692. Both the SNP and the methylation marker map to the MBD4, with the SNP in an intron and the methylation marker just upstream of the coding region [23177740].



Assays: Organismal Lifespan

Classification:
  • Aging Associated


  • References:
  • 23177740: Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MBD4 (9606)
  • MBD4 (9598)
  • MBD4 (9913)
  • Mbd4 (10090)
  • Mbd4 (10116)

  • Inparanoids
  • ENSMUSP00000032469 (10090)
  • ENSRNOP00000014537 (10116)
  • ENSMMUP00000016705 (9544)



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