wrn-1

Symbol: wrn-1
Name: human WRN (Werner's syndrome) related
Entrez gene ID: 174081
Species: Worm (Taxid: 6239)


Observation:

RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755].

A nonfunctional wrn-1 DNA helicase decreases the lifespan. The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced. Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628].



Interventions:
  • wrn-1 RNAi
  • wrn-1 mutation

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 23075628: Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
  • 15115755: A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • WRN (9606)
  • WRN (9598)
  • WRN (9615)
  • Wrn (10090)
  • WRN (9031)
  • LOC569495 (7955)
  • wrn-1 (6239)
  • Os07g0681600 (4530)



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