Symbol: wrn-1 Name: human WRN (Werner's syndrome) related Entrez gene ID: 174081 Species: Worm (Taxid: 6239) Observation: RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755]. A nonfunctional wrn-1 DNA helicase decreases the lifespan. The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced. Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628]. Interventions: Assays: Organismal Lifespan Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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