GHR

Symbol: GHR
Name: growth hormone receptor
Entrez gene ID: 2690
Ensembl gene ID: ENSG00000112964
Species: Human (Taxid: 9606)

Function:
Growth hormone binding protein

Observation:

Individuals with low GH/IGF-I signaling due to a defect in the growth hormone receptor (GHR) are protected against cancer. Among the human individuals with a defect in GHR no cancer deaths were observed. GHR deficiency does not appear to extend lifespan because it is associated with increased risk of heart disease [21325617]. Variants in GHR were found to be associated with longevity [19489743].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs12153009 0.033 [19489743]
  • rs2940923 0.0013 [19489743]
  • rs2940935 0.0031 [19489743]
  • rs3764451 0.094 [19489743]
  • rs4292454 0.39 [19489743]
  • rs4866941 0.19 [19489743]
  • rs6883523 0.52 [19489743]
  • rs6887528 0.25 [19489743]

  • Classification:
  • Aging Associated
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene

    References:
  • 21325617: Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
  • 19489743: Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • GHR (9606)
  • GHR (9598)
  • GHR (9615)
  • GHR (9913)
  • Ghr (10090)
  • Ghr (10116)
  • GHR (9031)
  • ghra (7955)

  • Orthologs
  • Ghr (10090)
  • Ghr (10090)

  • Inparanoids
  • ENSMUSP00000069457 (10090)
  • ENSRNOP00000044119 (10116)
  • ENSMMUP00000001785 (9544)



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