|
Symbol: eat-3 Name: EATing: abnormal pharyngeal pumping Entrez gene ID: 174476 Ensembl gene ID: D2013.5 Species: Worm (Taxid: 6239) Functional description: Protein EAT-3; EATing: abnormal pharyngeal pumping family member (eat-3) [Source:RefSeq peptide;Acc:NP_495986] [Ensembl]; eat-3 encodes a mitochondrial dynamin family member, closely related to bacterial dynamin-like proteins, that is orthologous to human Opa1 (OMIM:203740, mutated in autosomal dominant optic atrophy) and budding yeast Mgm1; eat-3 is required for proper regulation of inner mitochondrial membrane fusion and normal mitochondrial function (oxidative phosphorylation); accordingly, eat-3 is also required for normal body size, growth rates, locomotion, and reproductive levels; eat-3 promoter fusions are expressed at high levels in the intestine, muscles, and neurons, with lower levels seen in other cell types; by similarity to its mammalian and yeast orthologs, EAT-3 is predicted to localize to the mitochondrial intermembrane space. [WormBase] Observation: The eat-3(ad426) allele extends lifespan by 10%. Lifespan extension is proposed to be similar to DR [9789046]. eat-1 mutants have defects in haryngeal feeding behavior [8462849]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit