Symbol: VMA1 Name: Vacuolar Membrane Atpase 1 Alias: CLS8; TFP1 Entrez gene ID: 851342 Ensembl gene ID: YDL185W Species: Yeast (Taxid: 4932) Function: VMA1 is the catalytic subunit of the peripheral-membrane-associated V1 sector of the vacuolar H+-ATPase (V-ATPase) and required for its activity [2139027]. Observation: Overexpression of VMA1 increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VMA1 overexpression significantly increases mean, median and maximum lifespan by 39 - 45%, 39 - 48% and 50 - 60%, respectively. DR (0.5% glucose restriction) does not further increase the lifespan of VMA1 overexpression strain [23172144]. Interventions: Assays: Replicative Lifespan Mean: +39.3 to +44.8 Median: +39.3 to +48.3 Maximum: +50.0 to +60.0 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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