VMA1

Symbol: VMA1
Name: Vacuolar Membrane Atpase 1
Alias: CLS8; TFP1
Entrez gene ID: 851342
Ensembl gene ID: YDL185W
Species: Yeast (Taxid: 4932)

Function:
VMA1 is the catalytic subunit of the peripheral-membrane-associated V1 sector of the vacuolar H+-ATPase (V-ATPase) and required for its activity [2139027].

Observation:

Overexpression of VMA1 increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VMA1 overexpression significantly increases mean, median and maximum lifespan by 39 - 45%, 39 - 48% and 50 - 60%, respectively. DR (0.5% glucose restriction) does not further increase the lifespan of VMA1 overexpression strain [23172144].



Interventions:
  • VMA1 overexpression +39.3 to +44.8% +39.3 to +48.3% +50.0 to +60.0 %

  • Assays: Replicative Lifespan
    Mean: +39.3 to +44.8
    Median: +39.3 to +48.3
    Maximum: +50.0 to +60.0

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • References:
  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • atp6v1al (7955)
  • atp6v1a (7955)
  • Vha68-1 (7227)
  • vma1 (4896)
  • TFP1 (4932)
  • KLLA0F05401g (28985)
  • GeneID:2678289 (148305)
  • NCU01207 (5141)
  • VHA-A (3702)
  • Os06g0662000 (4530)
  • Os02g0175400 (4530)
  • vapA (5833)



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