Psa

Symbol: Psa
Name: Puromycin sensitive aminopeptidase
Entrez gene ID: 38175
Ensembl gene ID: FBgn0261243
Species: Fly (Taxid: 7227)

Function:
peptidase

Observation:

Psa exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages except 50 days [23106705]. Experimental u-regulation of Psa protects against tau-induced neurodegeneration [16950154].



Assays: Organismal Lifespan

Classification:
  • Longevity-Associated
  • Longevity-Differential
  • Longevity-Induced


  • References:
  • 23106705: GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.
  • 16950154: A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • NPEPPS (9606)
  • NPEPPS (9598)
  • NPEPPS (9615)
  • NPEPPS (9913)
  • Npepps (10090)
  • Npepps (10116)
  • NPEPPS (9031)
  • npepps (7955)
  • Psa (7227)
  • AgaP_AGAP005728 (7165)
  • pam-1 (6239)
  • ape2 (4896)
  • APE2 (4932)
  • KLLA0C11033g (28985)
  • AGOS_AAL127W (33169)
  • GeneID:2682253 (148305)
  • NCU09228 (5141)
  • APM1 (3702)
  • Os02g0218200 (4530)

  • Inparanoids
  • FBpp0072583 (7227)
  • ENSMUSP00000001480 (10090)
  • ENSRNOP00000033290 (10116)
  • ENSMMUP00000007725 (9544)
  • ENSP00000320324 (9606)
  • YHR047C (4932)
  • SPBC1921.05 (4896)



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