Symbol: Psa
Name: Puromycin sensitive aminopeptidase
Entrez gene ID: 38175
Ensembl gene ID: FBgn0261243
Species: Fly
(Taxid: 7227)
Function:
peptidase
Observation:
Psa exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages except 50 days [23106705]. Experimental u-regulation of Psa protects against tau-induced neurodegeneration [16950154].
Assays:
Organismal Lifespan
Classification:
Longevity-Associated
Longevity-Differential
Longevity-Induced
References:
23106705: GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.
16950154: A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
NPEPPS
(9606)
NPEPPS
(9598)
NPEPPS
(9615)
NPEPPS
(9913)
Npepps
(10090)
Npepps
(10116)
NPEPPS
(9031)
npepps
(7955)
Psa
(7227)
AgaP_AGAP005728
(7165)
pam-1
(6239)
ape2
(4896)
APE2
(4932)
KLLA0C11033g
(28985)
AGOS_AAL127W
(33169)
GeneID:2682253
(148305)
NCU09228
(5141)
APM1
(3702)
Os02g0218200
(4530)
Inparanoids
FBpp0072583 (7227)
ENSMUSP00000001480 (10090)
ENSRNOP00000033290 (10116)
ENSMMUP00000007725 (9544)
ENSP00000320324 (9606)
YHR047C (4932)
SPBC1921.05 (4896)
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