Denigma

Doc3

Symbol: Doc3
Name: Dorsocross3
Entrez gene ID: 39036
Ensembl gene ID: FBgn0035954
Species: Fly (Taxid: 7227)

Function:
Actin cytoskeleton organization

Observation:

Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].

Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596].



Assays: Organismal Lifespan

Classification:
  • Longevity-Associated


    • References:
  • 23106705: GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.
  • 19481596: A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • TBX6 (9606)
  • TBX6 (9598)
  • TBX6 (9615)
  • TBX6 (9913)
  • Tbx6 (10090)
  • Tbx6 (10116)
  • Doc1 (7227)
  • Doc3 (7227)
  • AgaP_AGAP005895 (7165)

    • Inparanoids
  • ENSMUSP00000073254 (10090)
  • ENSRNOP00000026806 (10116)



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