Name: interleukin 6 (interferon, beta 2)
Alias: HGF; HSF; BSF2; IL-6; IFNB2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; IFN-beta-2; hybridoma growth factor; interferon beta-2; interleukin BSF-2; interleukin-6
Entrez gene ID: 3569
Ensembl gene ID: ENSG000001
Species: Human (Taxid: 9606)
Interleukin that acts as both a pro- and anti-inflammatory cytokine.
Elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. The proportion of homozyogtes for the G allele at -174 locus (a promoter genetic variability) decreases centenarian males, but not centenarians females. Only males, homozygous for the G allele at -174 locus have higher IL6- serum levels. Individuals who are genetically predisposed to produce high levels of IL-6 during aging (i.e. -174 locus GG homozygous men) are disadvantaged for longevity .
Assays: Organismal Lifespan
Longevity Associated Variants:
Aging Relevance Analysis/Source:
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