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Symbol: fabp Name: fatty acid bindin protein Entrez gene ID: 3772232 Ensembl gene ID: FBgn0037913 Species: Fly (Taxid: 7227) Function: CG6783 encodes the fatty-acid-binding protein fabp which facilitates the intracellular movement of fatty acids, thus permitting the initiation of fatty-acid oxidation [7644552]. Observation: Overexpression of fabp (CG6783) throughout the whole body increases mean, median and maximum lifespan by 77, 81 and 13%, increases stress resistant (to paraquat but not starvation), consistently reduces mortality rate across adult ages and reduces the lifespan extension of DR by 12% [22997544]. fabp overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of fabp [22997544]. Females of the genotype Act-GS-Gal4 > UAS-CG6783 exhibit an increase in median lifespan compared to uninduced control in response to feeding with RU486-containing food from day 3 of adulthood (P < 0.0001). Mean lifespan is extended by 10, while maximum lifespan is decreased by 11% [22997544]. Interventions: Assays: Organismal Lifespan Mean: +77 Median: +81 Maximum: +13 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Note: Why does UAS overexpression of fabp in females decreases maximum lifespan? Edit \ Update (Admin) | Delete |
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