Name: translocase of outer mitochondrial membrane 40 homolog (yeast)
Alias: APOE; APOC1
Entrez gene ID: 10452
Ensembl gene ID: ENSG00000130204
Species: Human (Taxid: 9606)
Mitochondrial function; Channel-forming unit of mitochondrial outer membrane translocase
TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease .
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively . TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity . TOMM40 was found to be associated with longevity .
Assays: Organismal Lifespan
Longevity Associated Variants:
Aging Relevance Analysis/Source:
Edit \ Update (Admin) | Delete