Denigma: Factor

PEP4

Symbol: PEP4
Name: carboxyPEPtidase Y-deficient 4
Entrez gene ID: 855949
Ensembl gene ID: YPL154C
Species: Yeast (Taxid: 4932)

Function:
Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates

Observation:

Overexpression of vacuolar aspartyl protease (PEP4) extends chronological lifespan by increasing cytosolic polyamine and S-adenosylmethionine (SAM) levels. Deletion of PEP4 results in both apoptotic and necrotic cell death during chronological aging [21593793]. PEP4 is not DR-essential [18690010].

Interventions:

PEP4 overexpression

Assays: Chronological Lifespan

Classification:

Aging-Suppressor

Positive Aging-Suppressor

References:

18690010: A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery.

21593793: The propeptide of yeast cathepsin D inhibits programmed necrosis.

Aging Relevance Analysis/Source:

GenAge