Denigma

pyk-1

Symbol: pyk-1
Name: PYruvate Kinase 1
Entrez gene ID: 172744
Ensembl gene ID: F25H5.3
Species: Worm (Taxid: 6239)

Function:
pyurvat kinase

Observation:

RNA interference of pyk-1 during adulthood significantly shortens the lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pyk-1 from hatching causes larval lethality. PYK-1 is downregulated in eat-2 mutants [22810224].

pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969].



Interventions:
  • pyk-1 RNAi
  • pyk-1 mutation

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


    • References:
  • 22810224: Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans.
  • 20974969: DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PKM2 (9606)
  • PKM2 (9598)
  • PKM2 (9615)
  • PKM2 (9913)
  • Pkm2 (10090)
  • Pkm2 (10116)
  • PKM2 (9031)
  • pkm2a (7955)
  • PyK (7227)
  • AgaP_AGAP004596 (7165)
  • F25H5.3 (6239)
  • ZK593.1 (6239)
  • pyk1 (4896)
  • CDC19 (4932)
  • KLLA0F23397g (28985)
  • AGOS_ADR368W (33169)
  • GeneID:2678267 (148305)
  • NCU06075 (5141)
  • AT5G56350 (3702)
  • AT4G26390 (3702)
  • Os01g0276700 (4530)



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