dor

Symbol: dor
Name: deep orange
Entrez gene ID: 31118
Ensembl gene ID: FBgn0000482
Species: Fly (Taxid: 7227)

Functional description:
Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. [UniProt]

Observation:

Loss-of-function mutation in dor reduces mean lifespan by 70 - 81% and maximum lifespan by 71 - 78% [17435236].



Interventions:
  • dor mutation -70 to -81% -71 to -78%

  • Assays: Organismal Lifespan
    Mean: -70 to -81
    Maximum: -71 to -78

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • VPS18 (9606)
  • VPS18 (9598)
  • VPS18 (9615)
  • VPS18 (9913)
  • Vps18 (10090)
  • Vps18 (10116)
  • VPS18 (9031)
  • vps18 (7955)
  • dor (7227)
  • AgaP_AGAP000983 (7165)
  • pep3 (4896)
  • GeneID:2684480 (148305)
  • NCU06183 (5141)
  • AT1G12470 (3702)
  • Os08g0178100 (4530)

  • Inparanoids
  • FBpp0070259 (7227)
  • ENSMUSP00000036915 (10090)
  • ENSRNOP00000018717 (10116)
  • ENSMMUP00000019091 (9544)
  • ENSP00000220509 (9606)
  • YLR148W (4932)
  • SPCC790.02 (4896)



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