Denigma

MAPK1

Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Alias: ERK2
Entrez gene ID: 5594
Ensembl gene ID: ENSG00000100030
Species: Human (Taxid: 9606)


Observation:

Overexpression of human MAPK1 (alias ERK2) confers resistance to heat shock and oxidative stress extends median chronological lifespan by 24% and was statistically non-addative with cyr1-1 mutation [17662940].MAPK1 was not found to be associated with longevity [23020224]. MAPK1 was found to be associated with longevity [23020224].



Interventions:
  • MAPK1 overexpression +24%

    • Assays: Chronological Lifespan Organismal Lifespan

    Longevity Associated Variants:
  • rs5749998 0.152 [23020224]
  • rs2266968 0.048 [23020224]
  • rs1892848 0.218 [23020224]
  • rs5999521 0.218 [23020224]

    • Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • Longevity-Associated
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • MAPK1 (9606)
  • MAPK1 (9598)
  • MAPK1 (9615)
  • MAPK1 (9913)
  • Mapk1 (10090)
  • Mapk1 (10116)
  • MAPK1 (9031)
  • mapk1 (7955)
  • rl (7227)
  • AgaP_AGAP009207 (7165)
  • mpk-1 (6239)
  • KSS1 (4932)
  • KLLA0A02497g (28985)
  • AGOS_ACL191C (33169)
  • ATMPK13 (3702)
  • PfMAP1 (5833)

    • Inparanoids
  • ENSP00000215832 (9606)
  • ENSMUSP00000023462 (10090)
  • ENSRNOP00000002533 (10116)
  • ENSMMUP00000016444 (9544)
  • YBL016W (4932)
  • SPAC31G5.09c (4896)
  • ENSP00000215832 (9606)



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