TSL1

Symbol: TSL1
Name: Trehalose Synthase Long chain 1
Entrez gene ID: 854872
Ensembl gene ID: YML100W
Species: Yeast (Taxid: 4932)


Observation:

Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) [22783207].

Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells [22783207].



Interventions:
  • TSL1 deletion +43%

  • Assays: Chronological Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPACUNK4.16c (4896)
  • TSL1 (4932)
  • TPS3 (4932)
  • KLLA0E11265g (28985)
  • AGOS_AER276C (33169)
  • GeneID:2678952 (148305)
  • NCU00793 (5141)



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