Name: Trehalose Synthase Long chain 1
Entrez gene ID: 854872
Ensembl gene ID: YML100W
Species: Yeast (Taxid: 4932)
Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) .
Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells .
Assays: Chronological Lifespan
Aging Relevance Analysis/Source:
Edit \ Update (Admin) | Delete