Denigma: Factor

let-4

Symbol: let-4
Name: LEThal 4
Alias: sym-5
Entrez gene ID: 181554
Ensembl gene ID: C44H4.2
Species: Worm (Taxid: 6239)

Functional description:
Protein LET-4; SYnthetic lethal with Mec family member (sym-5) [Source:RefSeq peptide;Acc:NP_510425] [Ensembl]; let-4 encodes an extracellular leucine-rich repeat only protein; let-4 was originally identified in a screen for essential genes, and let-4 mutants exhibit early larval lethality; let-4 is required for organization of the apical extracellular matrix, and is involved in excretory cell canal morphology and renal function as mutants exhibit excretory canal cysts and impaired renal function. [WormBase]

Observation:

let-4 (alias sym-5) is downregulated in space. RNA intereference of let-4 extends mean and 75%ile lifespan by 4%, but reduces maximum lifespan by 25% [22768380].

Interventions:

let-4 RNAi +4% -25%

Assays: Organismal Lifespan

Classification:

Aging Associated

References:

22768380: Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

Aging Relevance Analysis/Source:

GenAge