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Symbol: shk-1 Name: SHaKer family of potassium channels 1 Entrez gene ID: 174536 Ensembl gene ID: ZK1321.2 Species: Worm (Taxid: 6239) Functional description: Protein SHK-1; Protein SHK-1, isoform a [Source:UniProtKB/TrEMBL;Acc:Q09658] [Ensembl] Observation: shk-1 encodes a shaker family of potassium channel which functions in muscle [21059759], is expressed in sensory neurons [16899454], and downregulated in space. Mutation or RNA interference of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1 RNAi extends mean, 75%ile, and maximum lifespan by 16, 15, and 22%. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants. RNAi inactivation of shk-1 reduces Q35 aggregation [22768380]. Mutation and RNAi of shk-1 enhance pheromone-induced dauer formation [22768380]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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