gar-3

Symbol: gar-3
Name: G-protein-linked Acetylcholine Receptor 3
Entrez gene ID: 179962
Ensembl gene ID: Y40H4A.1a
Species: Worm (Taxid: 6239)

Functional description:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [UniProt]

Observation:

gar-3 encodes a acetycholine receptor which is expressed in motor neurons and muscle [17287516], participates in acetylcholine transmission in motor neuron-muscle signalling, and is downregulated in space. Mutation or RNA interference of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3 RNAi extends mean, 75%ile, and maximum lifespan by 11, 14 an 17%. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2. RNAi inactivation of gar-3 reduces Q35 aggregation [22768380].



Interventions:
  • gar-3 RNAi +11% +17%
  • gar-3 mutation +5 to +18% +15 to +56%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CHRM1 (9606)
  • CHRM1 (9598)
  • CHRM1 (9615)
  • CHRM1 (9913)
  • Chrm1 (10090)
  • Chrm1 (10116)
  • LOC792708 (7955)
  • mAcR-60C (7227)
  • GPRMAC1 (7165)
  • gar-3 (6239)



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