Denigma: Factor

tdp-1

Symbol: tdp-1
Name: TAR DNA-binding Protein homolog 1
Alias: tag-169
Entrez gene ID: 174436
Ensembl gene ID: F44G4.4
Species: Worm (Taxid: 6239)

Functional description:
Protein TDP-1; Temporarily Assigned Gene name family member (tag-169) [Source:RefSeq peptide;Acc:NP_001022166] [Ensembl]

Observation:

tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012].

Interventions:

tdp-1 mutation

tdp-1 RNAi

tdp-1 overexpression

Assays: Organismal Lifespan

Classification:

Gerontogene

Negative Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge