Lep

Symbol: Lep
Name: leptin
Entrez gene ID: 16846
Ensembl gene ID: ENSMUSG00000059201
Species: Mouse (Taxid: 10090)

Functional description:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. [UniProt]

Observation:

Lep knockout results in ob/ob mice which eats excessively and becomes profoundly obese. ob/ob mice live shorter on ad libitum, but achieve a lifespan similiar to control levels under DR, yet their precentage of body fat is much greater that that of controls [6608731].



Interventions:
  • Lep knockout

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • LEP (9606)
  • LEP (9598)
  • LEP (9615)
  • LEP (9913)
  • Lep (10090)
  • Lep (10116)

  • Inparanoids
  • ENSRNOP00000008020 (10116)
  • ENSMUSP00000067046 (10090)
  • ENSMUSP00000067046 (10090)



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