Symbol: ACH1
Name: Acetyl CoA Hydrolase 1
Entrez gene ID: 852266
Ensembl gene ID: YBL015W
Species: Yeast (Taxid: 4932)

Functional description:
Ach1p; Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth [Source:SGD;Acc:S000000111] [Ensembl]


ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872].

  • ACH1 deletion -32%

  • Assays: Chronological Lifespan

  • Aging-Suppressor
  • Negative Aging-Suppressor

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPAC1952.09c (4896)
  • ACH1 (4932)
  • KLLA0E10561g (28985)
  • AGOS_AFR020W (33169)
  • GeneID:2684764 (148305)
  • NCU09770 (5141)

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