dod-18

Symbol: dod-18
Name: Downstream Of DAF-16 (regulated by DAF-16)
Entrez gene ID: 183813
Ensembl gene ID: C54G4.6
Species: Worm (Taxid: 6239)

Functional description:
Protein DOD-18; Downstream Of DAF-16 (regulated by DAF-16) family member (dod-18) [Source:RefSeq peptide;Acc:NP_492205] [Ensembl]; dod-18 encodes a Maf-like protein required for normally short lifespan; dod-18 is repressed in daf-2 mutants and induced in daf-16 mutants, and dod-18(RNAi) lengthens lifespan by 30%; MAF-like proteins are ubiquitous among eukarya, bacteria, and archaea; DOD-18 is orthologous to the N-terminal ~200 residues of human ASMTL (OMIM:300162), and to Bacillus subtilis Maf (Multicopy Associated Filamentation) protein, which inhibits septum formation; while the specific biochemical function of Maf-like proteins is unknown, the tertiary structure of B. subtilis Maf is consistent with its binding nucleic acid. Other DOD-18 orthologs include budding yeast YOR111W, fission yeast SPAC3G6.03c, and Escherichia coli yhdE. [WormBase]

Observation:

RNA interference of dod-18 extends lifespan by 30%. dod-18 is differentially transcriped in daf-16 and daf-2 RNAi animals [12845331].



Interventions:
  • dod-18 RNAi +30%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ASMTL (9606)
  • ASMTL (9598)
  • ASMTL (9615)
  • ASMTL (9031)
  • asmtl (7955)
  • CG9515 (7227)
  • AgaP_AGAP008707 (7165)
  • dod-18 (6239)
  • SPAC3G6.03c (4896)
  • YOR111W (4932)
  • KLLA0F23628g (28985)
  • AGOS_AFL225W (33169)
  • GeneID:2679529 (148305)
  • NCU03130 (5141)



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