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Symbol: unc-24 Name: UNCordinated 24 Entrez gene ID: 177594 Ensembl gene ID: F57H12.2 Species: Worm (Taxid: 6239) Functional description: Predicted to be a plasma membrane channel; Protein UNC-24; UNCoordinated family member (unc-24) [Source:RefSeq peptide;Acc:NP_501335] [Ensembl]; unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord. [WormBase] Observation: Mutations in unc-24 have no significant effect on lifespan [9789046] and unc-24(e138) fails to extend male lifespan [10747056]. unc-24 mutant is uncoordinated and displays irregular movement [4366476; 8667025]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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