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Symbol: unc-2 Name: UNCoordinated 2 Entrez gene ID: 180570 Ensembl gene ID: T02C5.5 Species: Worm (Taxid: 6239) Functional description: Protein UNC-2; UNCoordinated family member (unc-2) [Source:RefSeq peptide;Acc:NP_001024871] [Ensembl]; unc-2 encodes a calcium channel alpha subunit required for desensitization to dopamine, normal flexion and speed during movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations promoted by humoral serotonin; UNC-2 is orthologous to human CACNA1A (OMIM:601011, mutated in familiar hemiplegic migraine or episodic ataxia 2) and to Drosophila CACOPHONY; UNC-2 is expressed primarily in motor neurons, several sensory neurons, and HSN and VC neurons controlling egg-laying. [WormBase] Observation: Loss of function in unc-2 has no effect on lifespan [9789046]. unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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